Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 26: 261-265, 1980;
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Greter, J.
Right arrow Articles by Steen, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Greter, J.
Right arrow Articles by Steen, G.

Clinical Chemistry, Vol 26, 261-265, Copyright © 1980 by American Association for Clinical Chemistry

3-hydroxydecanedioic acid and related homologues: urinary metabolites in ketoacidosis

J Greter, S Lindstedt, H Seeman and G Steen

Urine from patients with ketoacidosis was found to contain a number of aliphatic 3-hydroxy dicarboxylic acids. The acids were purified by silicic acid chromatography and their structures determined by gas chromatography-mass spectrometry of different derivatives. The major compound was 3-hydroxydecanedioic acid. Minor compounds were 3- hydroxyoctanedioic acid, 3-hydroxyoctenedioic acid, 3- hydroxydecenedioic acid, 3-hydroxydodecanedioic acid, 3- hydroxydodecenedioic acid, 3-hydroxytetradecenedioic acid, and 3- hydroxytetradecadienedioic acid. The excretion of 3-hydroxydecanedioic acid correlated positively with the excretion of hexanedioic acid, another metabolite constantly found in ketoacidosis (Pettersen et al., Clin. Chim. Acta 38: 17-24, 1972). We suggest that the 3-hydroxy dicarboxylic acids are formed from fatty acids by a combination of omega-oxidation and incomplete beta-oxidation.


The following articles in journals at HighWire Press have cited this article:


Home page
 J. Lipid Res.Home page
M. Dhar, D. W. Sepkovic, V. Hirani, R. P. Magnusson, and J. M. Lasker
Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11
J. Lipid Res., March 1, 2008; 49(3): 612 - 624.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. Kumps, P. Duez, and Y. Mardens
Metabolic, Nutritional, Iatrogenic, and Artifactual Sources of Urinary Organic Acids: A Comprehensive Table
Clin. Chem., May 1, 2002; 48(5): 708 - 717.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by the American Association for Clinical Chemistry.