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Clinical Chemistry 26: 295-296, 1980;
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Clinical Chemistry, Vol 26, 295-296, Copyright © 1980 by American Association for Clinical Chemistry

Gas-chromatographic determination of amantadine in human urine

MJ Stumph, MW Noall and V Knight

We describe a gas--liquid-chromatographic method for determining the concentration of amantadine hydrochloride in urine with beta- phenylethylamine as internal standard. The urine sample is made alkaline and extracted with 0.5 mL of chloroform. After centrifugation the aqueous layer is aspirated, and an aliquot of the organic layer is injected directly into the gas chromatograph. Concentration and instrument response are linearly related between 2 and 125 mg/L. The limit of detection was 0.5 mg/L. Mean analytical recovery was calculated to be 97%.




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Copyright © 1980 by the American Association for Clinical Chemistry.