Clinical Chemistry
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Clinical Chemistry 26: 341-343, 1980;
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Clinical Chemistry, Vol 26, 341-343, Copyright © 1980 by American Association for Clinical Chemistry

Adaptation of the enzyme-multiplied immunoassay for methotrexate to the centrifugal analyzer

PR Finley, RJ Williams, F Griffith and DA Lichti

We adapted the homogeneous enzyme-multiplied immunoassay for methotrexate to the centrifugal analyzer. The sensitivity of the assay has been extended from 200 nmol/L down to 12.5 nmol/L. Several protocols may be followed, depending on whether the samples to be tested are from patients on low- or high-dose methotrexate regimens. Precision, accuracy, and sensitivity were satisfactory. Comparison with the enzymic-inhibition method (x) gave the following least-squares regression: y = 1.002 x - 0.013 mumol/L; r2 = 0.9721; Sy/x = 0.014 mumol/L.




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Copyright © 1980 by the American Association for Clinical Chemistry.