Clinical Chemistry
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Clinical Chemistry 26: 343-345, 1980;
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Clinical Chemistry, Vol 26, 343-345, Copyright © 1980 by American Association for Clinical Chemistry

Two agarose electrophoretic systems for demonstration of oligoclonal bands in cerebrospinal fluid compared

B Gerson, FJ Krolikowski and IM Gerson

Demonstration of oligoclonal bands by electrophoresis of cerebrospinal fluid is an important aid in establishing the diagnosis of multiple sclerosis. Electrophoretic systems vary in their effectiveness in doing so. We compared two systems in this respect. For a thin-layer agarose system, sensitivity was less (47%) than for a high-resolution agarose system (87%). Each system had good specificity (92 and 85%, respectively). Interpretation of electrophoretic patterns for cerebrospinal fluid should be available in clinical laboratories. Further, the best available system should be used for demonstration of oligoclonal bands.


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 Arch NeurolHome page
J. T. Caroscio, S. Kochwa, H. Sacks, J. A. Cohen, and M. D. Yahr
Quantitative CSF IgG Measurements in Multiple Sclerosis and Other Neurologic Diseases: An Update
Arch Neurol, July 1, 1983; 40(7): 409 - 413.
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