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Clinical Chemistry 26: 457-462, 1980;
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Clinical Chemistry, Vol 26, 457-462, Copyright © 1980 by American Association for Clinical Chemistry

Further heterogeneity demonstrated for serum creatine kinase isoenzyme MM

JP Chapelle and C Heusghem

Serum creatine kinase (EC 2.1.3.2) isoenzyme MM was resolved by isoelectric focusing into a five-band pattern, a pattern that gradually changed after the onset of myocardial infarction. Similar changes were also demonstrated in patients undergoing coronary-bypass surgery. The evolution of two CK-MB sub-bands was studied in both cases. We found that three electrophoretic bands (CK-MM, pI 7.10; MM1, pI 6.88; MB1, pI 5.61) were predominant in patterns for sera collected during the early phase of myocardial infarction, but rapidly disappeared during the following hours, whereas bands of increased electrophoretic mobility (MM2, pI 6.70; MM3, pI 6.45; MM4, pI 6.25; MB2, pI 5.34) gradually increased. MM3 was always the major band at the end of the observation period in acute myocardial infarction (mean, 61.4% of total creatine kinase activity 36 h after the peak value for total creatine kinase in serum). The CK-MM bands were also present in the serum of patients without heart disease. Changes in the electrophoretic pattern were induced by a thermolabile factor in normal human serum, which transformed the muscular or myocardial MM and MM1 bands after their release into the blood stream.


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M. Nussinovitch, G. Klinger, G. Soen, A. Magazanik, B. Volovitz, I. Varsano, and A. Nussinovitch
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Copyright © 1980 by the American Association for Clinical Chemistry.