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Clinical Chemistry 26: 463-465, 1980;
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Clinical Chemistry, Vol 26, 463-465, Copyright © 1980 by American Association for Clinical Chemistry

Thyroxine-binding globulin capacity and concentration evaluated from blood spots on filter-paper in a screening program for neonatal hypothyroidism

JH Dussault, J Morissette, J Letarte, H Guyda and C Laberge

We describe a simple method for evaluating thyroxine-binding globulin capacity and concentration from a single 1-cm blood spot on filter- paper used in a screening program for neonatal hypothyroidism. This method permits prompt diagnosis of about 90% of the infants with thyroxine-binding globulin deficiency in our abnormal low-thyroxine, low-thyrotropin population. There was excellent equivalence between results obtained by our method and by the method of Chopra et al. (J. Clin. Endocrinol. Metab. 35:565, 1972), and minimal overlap between the population with low thyroxine-binding globulin and the low-thyroxine, normal thyrotropin population. We recommend this method to all programs in which a primary thyroxine measurement is used in screening for congenital hypothyroidism.


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Home page
 J. Clin. Endocrinol. Metab.Home page
The Anecdotal History of Screening for Congenital Hypothyroidism
J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4332 - 4334.
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