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Clinical Chemistry, Vol 26, 598-600, Copyright © 1980 by American Association for Clinical Chemistry
NP Kubasik, M Ricotta and HE Sine
Recent evidence (Kolhouse et al., N. Engl. J. Med. 299: 785-792, 1978) demonstrates that commercial cobalamin (Vitamin B12) radioassay kits contain nonspecific R-protein binding agents that can give falsely normal results in patients who are actually cobalamin deficient. We tested three kits: with "purified" intrinsic factor as the binder, with intrinsic factor and the nonspecific R-protein sites blocked with "cobinamide," and non-purified intrinsic factor-R-protein binder. Results with use of the first two compared well with those by a microbiological assay (Lactobacillus leichmannii) and are in harmony with clinical impressions.
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C. M. Loria, D. D. Ingram, J. J. Feldman, J. D. Wright, and J. H. Madans Serum Folate and Cardiovascular Disease Mortality Among US Men and Women Arch Intern Med, November 27, 2000; 160(21): 3258 - 3262. [Abstract] [Full Text] [PDF] |
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