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Clinical Chemistry 26: 609-612, 1980;
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Clinical Chemistry, Vol 26, 609-612, Copyright © 1980 by American Association for Clinical Chemistry

Properties and clinical significance of an alkaline phosphatase- lipoprotein-X complex

RN Weijers

The existence of an alkaline phosphatase-lipoprotein-X complex was demonstrated as an abnormally moving band in the agar-agarose gel alkaline phosphatase pattern of sera from 58 patients in a group of 72 patients whose sera contained lipoprotein-X. The position of the abnormally moving band in the agar-agarose gel alkaline phosphatase pattern and the percentage of alkaline phosphatase activity in the complex in relation to the total serum alkaline phosphatase activity depend on the serum lipoprotein-X concentration. The presence of the complex is a reliable indicator for cholestasis and of limited value in the differentiation between intrahepatic and extrahepatic cholestasis.




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