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Clinical Chemistry 26: 763-765, 1980;
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Clinical Chemistry, Vol 26, 763-765, Copyright © 1980 by American Association for Clinical Chemistry

Simplified approach to confidence limited in radioimmunassay

RC Baxter

A simple method of calculating confidence limits for radioimmunoassay data is presented. The method involves the use of the within-assay variation in dose estimate of three routine quality-control specimens, measured in repeated assays, to estimate the confidence limits for results on unknown samples. Results for control specimens are combined by calculating the unique quadratic curve fitting a graph of within- assay standard deviation vs mean value for each control. This method requires no special data accumulation or advanced computing equipment. For cortisol, lutropin, and thyroxine radioimmunoassays, confidence limits calculated in this way have been compared with those calculated from the variance of the response variable "B/B0" in repeated standard curves. Both methods agree well with actual limits observed when plasma pools containing a wide range of hormone concentrations are assayed repeatedly.


The following articles in journals at HighWire Press have cited this article:


Home page
 Ann Clin BiochemHome page
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Error models for immunoassays
Ann Clin Biochem, September 1, 2008; 45(5): 481 - 485.
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