Clinical Chemistry
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Clinical Chemistry 26: 861-866, 1980;
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Clinical Chemistry, Vol 26, 861-866, Copyright © 1980 by American Association for Clinical Chemistry

Creatine kinase radioimmunoassay and isoenzyme electrophoresis compared in the diagnosis of acute myocardial infarction

HA Homburger and GL Jacob

We compared, in 116 patients, the relative usefulness of results of tests for creatine kinase B isoenzymes, as measured by radioimmunoassay, and the MB isoenzyme, as measured by electrophoresis, in diagnosis of acute myocardial infarction. The radioimmunoassay was specific for isoenzymes of creatine kinase containing the B subunit. All patients with acute transmural infarcts had positive test results by both techniques, but concentrations of B-isoenzymes were more frequently above normal than were MB bands in the case of patients with acute subendocardial infarcts and in the case of all patients with acute myocardial infarcts from whom sera were collected more than 24 h after onset of chest pain. Concentrations of B-isoenzymes also were increased, even when MB bands were not electrophoretically detectable, in specimens from several patients without documented actue myocardial infarcts. These abnormal results presumably were caused by increased concentrations of the BB isoenzyme in serum. Accordingly, an increased concentration of B-isoenzymes had less diagnostic specificity and predictive value for acute myocardial infarction than did a detectable MB band. Results of isoenzyme electrophoresis were more reliable for establishing this diagnosis, but the results of radioimmunoassay were more reliable for excluding it in patients with chest pain as the primary symptom.


The following articles in journals at HighWire Press have cited this article:


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 Arch NeurolHome page
F. E. Pfeiffer, H. A. Homburger, and T. Yanagihara
Serum Creatine Kinase B Concentrations in Acute Cerebrovascular Diseases
Arch Neurol, November 1, 1984; 41(11): 1175 - 1178.
[Abstract] [PDF]

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 Arch NeurolHome page
F. E. Pfeiffer, H. A. Homburger, and T. Yanagihara
Creatine Kinase BB Isoenzyme in CSF in Neurologic Diseases: Measurement by Radioimmunoassay
Arch Neurol, March 1, 1983; 40(3): 169 - 172.
[Abstract] [PDF]

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 ANN INTERN MEDHome page
M. C. GEOKAS, R. S. YALOW, E. W. STRAUS, and E. M. GOLD
Peptide Radioimmunoassays in Clinical Medicine
Ann Intern Med, September 1, 1982; 97(3): 389 - 407.
[Abstract] [PDF]


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Copyright © 1980 by the American Association for Clinical Chemistry.