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Clinical Chemistry 26: 903-907, 1980;
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Clinical Chemistry, Vol 26, 903-907, Copyright © 1980 by American Association for Clinical Chemistry

Applicability of various quality-control sera to assay of high-density lipoprotein cholesterol

DG Bullock, TJ Carter and SV Hughes

Effective internal quality control and external quality assessment of high-density lipoprotein cholesterol assay is made difficult by analyte instability, and the suitability of quality-control sera for this purpose has not been studied. We have therefore investigated the properties of 25 different control sera from 15 suppliers by estimating within-batch precision for the two precipitation procedures used most widely (phosphotungstate/Mg2+ and heparin/Mn2+ with enzymic measurement of cholesterol. Some sera had properties similar to those of fresh human serum, but others demonstrated poor precision for one or both procedures or contained apparent high-density lipoprotein cholesterol in unphysiological concentrations. A study of six sera indicated that between-batch precision was consistent with the within-batch findings. We found that eight of the 25 batches of quality-control serum we investigated may be used for internal quality control and external quality assessment of high-density lipoprotein cholesterol assay.




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Copyright © 1980 by the American Association for Clinical Chemistry.