Clinical Chemistry
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Clinical Chemistry 26: 1351-1354, 1980;
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Clinical Chemistry, Vol 26, 1351-1354, Copyright © 1980 by American Association for Clinical Chemistry

Improved liquid-chromatographic determination of caffeine in plasma

J Blanchard, JD Mohammadi and KA Conrad

We describe a rapid, specific, and sensitive liquid-chromatographic micro-method for caffeine in plasma. Each plasma sample can be assayed within about 15 min of its receipt. Samples are denatured with acetonitrile, centrifuged, and the supernate is chromatographed on a reversed-phase column. Only 100 microL of plasma is required, and concentrations as low as 0.3 mg/L can be measured accurately. Other xanthines and their metabolites do not interfere. The small sample required makes the procedure ideally suited for measuring caffeine in the plasma of infants and small animals as well as adults.


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 Arch Intern MedHome page
T. B. Graboys, C. M. Blatt, and B. Lown
The Effect of Caffeine on Ventricular Ectopic Activity in Patients With Malignant Ventricular Arrhythmia
Arch Intern Med, March 1, 1989; 149(3): 637 - 639.
[Abstract] [PDF]


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Copyright © 1980 by the American Association for Clinical Chemistry.