Clinical Chemistry
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Clinical Chemistry 27: 133-134, 1981;
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Clinical Chemistry, Vol 27, 133-134, Copyright © 1981 by American Association for Clinical Chemistry

Relation between maternal weight and serum alpha-fetoprotein concentration during the second trimester

JE Haddow, EM Kloza, GJ Knight and DE Smith

Maternal serum alpha-fetoprotein concentrations are influenced by maternal weight during the second trimester. Heavier pregnant women have lower median values, apparently as a result of a diluting effect of larger blood volume. This phenomenon is of clinical interest because alpha-fetoprotein concentration in a pregnant woman's serum is one of the factors considered in assessing risk of poor outcome. A revision of the reference interval for alpha-fetoprotein to take body weight into account might improve its use as a diagnostic aid, especially in heavier women.


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G. J. Mizejewski
Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome
Experimental Biology and Medicine, September 1, 2007; 232(8): 993 - 1004.
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T M Reynolds, G Vranken, and J Van Nueten
Weight correction of MoM values: which method?
J. Clin. Pathol., July 1, 2006; 59(7): 753 - 758.
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M. M. Werler, C. Louik, S. Shapiro, and A. A. Mitchell
Prepregnant Weight in Relation to Risk of Neural Tube Defects
JAMA, April 10, 1996; 275(14): 1089 - 1092.
[Abstract] [PDF]

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Questions and Answers
JAMA, September 23, 1988; 260(12): 1779 - 1782.
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Copyright © 1981 by the American Association for Clinical Chemistry.