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Clinical Chemistry 27: 1655-1657, 1981;
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Clinical Chemistry, Vol 27, 1655-1657, Copyright © 1981 by American Association for Clinical Chemistry

Immunoreactive trypsin and pancreatic isoamylase activity in serum of patients with chronic renal failure or hepatic cirrhosis

J Fahrenkrug, P Staun-Olsen and E Magid

In 121 patients with either liver cirrhosis or chronic renal failure, abnormal values for the concentrations of two pancreatic enzymes in serum were a frequent finding. In renal insufficiency a decreased rate of enzyme elimination is the most likely cause of the above-normal values we observed for serum immunoreactive trypsin and pancreatic isoamylase activity. As for patients with liver cirrhosis, we believe that changes in entrance rates into the blood--i.e., an affected pancreas--is a likely explanation of the abnormally high values we often found for these serum enzymes.




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Copyright © 1981 by the American Association for Clinical Chemistry.