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Clinical Chemistry 27: 1661-1664, 1981;
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Clinical Chemistry, Vol 27, 1661-1664, Copyright © 1981 by American Association for Clinical Chemistry

(omega-1)-Hydroxymonocarboxylic acids in urine of infants fed medium- chain triglycerides

Y Shigematsu, T Momoi, M Sudo and Y Suzuki

Organic acids in the urine of infants fed a formula containing medium- chain triglycerides (octanoic acid 49% and decanoic acid 26% of total fatty acids) were determined by gas chromatography-mass spectrometry. We found a considerable amount of 5-hydroxyhexanoic acid and 7- hydroxyoctanoic acid, but no detectable 9-hydroxydecanoic acid, as well as a large amount of C6-C10-dicarboxylic acid. We believe that such acids are derived, via (omega-1)-hydroxylation, from medium-chain monocarboxylic acid or medium-chain acyl-CoA in the liver cell. The degree of (omega-1)-hydroxylation of medium-chain fatty acids relative to omega-hydroxylation apparently increases as the chain length of the fatty acids decreases.


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R. B. Lee, L. L. Duncan, and K. S. Roth
Dietary Medium-Chain Triglycerides: A Source of Urinary Dicarboxylic Acids and Diagnostic Confusion
Clinical Pediatrics, April 1, 2001; 40(4): 225 - 227.
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Copyright © 1981 by the American Association for Clinical Chemistry.