Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 27: 1733-1737, 1981;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brett, E. M.
Right arrow Articles by Hicks, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brett, E. M.
Right arrow Articles by Hicks, J. M.

Clinical Chemistry, Vol 27, 1733-1737, Copyright © 1981 by American Association for Clinical Chemistry

Total-calcium measurement in serum from neonates: limitations of current methods

EM Brett and JM Hicks

In the routine analysis for calcium in serum from neonates we noted large discrepancies in icteric samples analyzed by several different methods. The present investigation was undertaken to demonstrate the magnitude of the problem of bilirubin interference in calcium analysis and to assess the specific applicability of commonly used micro-methods in the pediatric or neonatal laboratory. The intention is not to advocate any single methodology but rather to point out inadequacies that must be considered. Colorimetric and fluorometric methods correlated poorly with an atomic absorption spectroscopic method for samples from pediatric patients. In addition, we noted significant interference proportional to the concentration of bilirubin. A fluorescence titration method was shown to be unacceptable for pediatric use because of the variable and unpredictable response to bilirubin interference. The study emphasizes the need for thorough invesigation of methods before they are put to use in the specialized pediatric setting.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the American Association for Clinical Chemistry.