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Clinical Chemistry 27: 1807-1820, 1981;
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Clinical Chemistry, Vol 27, 1807-1820, Copyright © 1981 by American Association for Clinical Chemistry

The TYCHO system for computer analysis of two-dimensional gel electrophoresis patterns

NL Anderson, J Taylor, AE Scandora, BP Coulter and NG Anderson

We describe here a computer system for the analysis of high-resolution two-dimensional gel-electrophoresis patterns, with some initial applications. The system (called TYCHO) comprises programs for image acquisition, background subtraction and smoothing, spot detection, gaussian spot modeling, and pattern matching and comparison. It is based on a conventional minicomputer, but makes extensive use of a high- speed array processor in the image-processing and -modeling steps. Used in concert with the ISO-DALT two-dimensional electrophoresis system (Anal. Biochem. 85:331-354, 1978), TYCHO allows quantitative measurement of hundreds of proteins in complex biological samples, and constitutes the initial data-reduction system required for work towards a Human Protein Index.


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Copyright © 1981 by the American Association for Clinical Chemistry.