Clinical Chemistry, Vol 27, 1821-1823, Copyright © 1981 by American Association for Clinical Chemistry

Lactate dehydrogenase isoenzyme-1: changes during the first day after acute myocardial infarction

DE Bruns, JC Emerson, S Intemann, R Bertholf, KE Hill Jr and J Savory

We studied the time course of change of lactate dehydrogenase isoenzyme- 1 (LD-1) in serum of patients suspected of having had an acute myocardial infarction. LD-1 was measured at intervals of 4-8 h during the first and second hospital days, by an immunochemical method. Of the 65 patients in this study, 26 had acute myocardial infarctions by traditional criteria. The ratio of LD-1 to total LD had greater diagnostic value than did LD-1 alone. In 90% of patients with myocardial infarction this ratio was increased within 12 h of admission, and all had increased ratios within 24 h. The false-positive rate was less than 1%, and an increased LD-1/total LD ratio had a predictive value of 96% for myocardial infarction. These results suggest that LD-1 is useful in the diagnosis of myocardial infarction on the first day of hospitalization.

The following articles in journals at HighWire Press have cited this article:

				P. C. Painter, S. Van Meter, R. L. Dabbs, and G. E. Clement Analytical Evaluation and Comparison of Dupont aca(R) Lactate Dehydrogenase-1 (LD1) Isoenzyme Assay Diagnostic Efficiency for Acute Myocardial Infarction Detection with Other LD1 Methods and aca@ CK-MB: A Two-Site Study Angiology, July 1, 1994; 45(7): 585 - 595. [Abstract] [PDF]

				M. T. McCoy, J. J. Aguanno, and S. E. Ritzmann Lactate Dehydrogenase Isoenzyme 1: A Rapid Assay for Ischemic Myocardial Disease Arch Intern Med, March 1, 1983; 143(3): 434 - 436. [Abstract] [PDF]