Clinical Chemistry
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Clinical Chemistry 27: 1872-1874, 1981;
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Clinical Chemistry, Vol 27, 1872-1874, Copyright © 1981 by American Association for Clinical Chemistry

Bilirubin binding and neonatal acidosis

M Perlman, J Kapitulnik, SH Blondheim, A Alayoff and A Russell

Plasma of neonates with severe metabolic acidosis secondary to fetal hypoxia bound less bilirubin than that of neonates without acidosis, as determined by Sephadex gel filtration. There was a significant correlation between the amount of bilirubin adsorbed by Sephadex and the base deficit. The method used ruled out any influence of plasma pH per se on binding. Our results suggest that organic anions that accumulate in the plasma of asphyxiated acidotic neonates may compete with bilirubin for binding sites on albumin.


The following articles in journals at HighWire Press have cited this article:


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J. M. Perlman, B. B. Rogers, and D. Burns
Kernicteric Findings at Autopsy in Two Sick Near Term Infants
Pediatrics, April 1, 1997; 99(4): 612 - 612.
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