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Clinical Chemistry 27: 1974-1977, 1981;
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Clinical Chemistry, Vol 27, 1974-1977, Copyright © 1981 by American Association for Clinical Chemistry

Myelin basic protein, oligoclonal bands, and IgG in cerebrospinal fluid as indicators of multiple sclerosis

B Gerson, SR Cohen, IM Gerson and GH Guest

There currently are three clinical laboratory procedures for use with cerebrospinal fluid that assist in the diagnosis of multiple sclerosis: measurement of myelin basic protein and IgG, and demonstration of an oligoclonal band. We compared characteristics of these procedures, using CSF samples from 166 patients identified as having (54 patients) or not having (112 patients) multiple sclerosis. We find that oligoclonal band demonstration is the most useful single test in helping to establish the presence of multiple sclerosis; IgG quantitation is the least helpful. Myelin basic protein should be quantitated for following the activity of multiple sclerosis; it may be applied only selectively in the context of screening. The incidence of false-positive results reinforces the view that the diagnosis of multiple sclerosis must be made in clinical context. These laboratory procedures are not suitable for use as screening tests.


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J. Rawes, V. Calabrese, O. Khan, and G. DeVries
Antibodies to the axolemma-enriched fraction in the cerebrospinal fluid and serum of patients with multiple sclerosis and other neurological diseases
Multiple Sclerosis, December 1, 1997; 3(6): 363 - 369.
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Copyright © 1981 by the American Association for Clinical Chemistry.