Clinical Chemistry
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Clinical Chemistry 27: 223-227, 1981;
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Clinical Chemistry, Vol 27, 223-227, Copyright © 1981 by American Association for Clinical Chemistry

Simultaneous determination of the four major catecholamine metabolites and estimation of a serotonin metabolite in urine by capillary gas chromatography of their tert-butyldimethylsilyl derivatives

FA Muskiet, MC Stratingh, GJ Stob and BG Wolthers

We have developed a routine capillary gas-chromatographic profiling method for simultaneous quantitative determination of the tert- butyldimethylsilyl derivatives of homovanillic acid, vanilmandelic acid, 3-methoxy-4-hydroxyphenylethylene glycol, and 3,4- dihydroxyphenylacetic acid and the estimation of 5-hydroxyindole-3- acetic acid in urine. The method is useful for diagnosis and followup of patients with functional tumors characterized by increased urinary excretion of metabolites originating from the metabolism of tyrosine and tryptophan--e.g., neuroblastoma, pheochromocytoma, carcinoid, and melanoma. It may also be applicable in pharmacokinetic studies of administered aromatic amino acids (parkinsonism, mental diseases, loading tests) and for diagnosis and followup of patients with inborn errors of metabolism that are characterized by organic aciduria (for instance, tyrosyluria and phenylketonuria).


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Copyright © 1981 by the American Association for Clinical Chemistry.