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Clinical Chemistry 27: 385-387, 1981;
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Clinical Chemistry, Vol 27, 385-387, Copyright © 1981 by American Association for Clinical Chemistry

New approach to cystic fibrosis diagnosis by use of an improved sweat- induction/collection system and osmometry

HL Webster and WK Barlow

A comprehensive equipment system is described that induces, collects, and analyzes sweat as a diagnostic procedure for cystic fibrosis. The safety and convenience of the iontophoretic induction phase have been improved by specially designed circuitry and electrodes. The problem of potentially serious error as a result of condensation within sweat- collection cups has been eliminated by use of a thermostatically controlled heated cup. The osmolality of the collected sweat is measured with a vapor-pressure osmometer. Data are presented to support the validity of osmolality as an alternative to electrolyte assay or electrical conductivity measurement and normal and abnormal ranges are provided. The complete system was tested in a pediatric hospital and data are presented to illustrate the relative advantages of the system with respect to safety, convenience, diagnostic reliability, and decreased potential for human error.


The following articles in journals at HighWire Press have cited this article:


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 J Biomol ScreenHome page
H. H. Parikh, V. Balasubramanian, W. L. Chul, M. E. Morris, and M. Ramanathan
Rapid Solubility Determination Using Vapor-Phase Osmometry
J Biomol Screen, December 1, 1999; 4(6): 315 - 318.
[Abstract] [PDF]

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 Postgrad. Med. J.Home page
R C C Lord
Current concepts: Osmosis, osmometry, and osmoregulation
Postgrad. Med. J., February 1, 1999; 75(880): 67 - 73.
[Abstract] [Full Text]


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Copyright © 1981 by the American Association for Clinical Chemistry.