Clinical Chemistry
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Clinical Chemistry 27: 721-726, 1981;
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Clinical Chemistry, Vol 27, 721-726, Copyright © 1981 by American Association for Clinical Chemistry

Laser nephelometry of orosomucoid in serum of newborns: reference intervals and relation to bacterial infections

J Bienvenu, L Sann, F Bienvenu, C Lahet, P Divry, J Cotte and M Bethenod

Orosomucoid was evaluated by laser-nephelometry in 1790 sera collected from 1170 newborns. Within-run precision (CV) was 2.1 to 4.2%, between- run 2.9 to 5.2%. Results correlated well with radial immunodiffusion (r = 0.989). Results can be obtained within 1 h. Orosomucoid concentrations in serum at birth range from 130 to 200 mg/L and are influenced by gestational age during the first two days of postnatal life. Thereafter, the values increase very rapidly in the first week of life, concentrations being the same as in adults by about 10 months. In 66 of 78 cases of severe bacterial infections, orosomucoid concentrations were above normal. Evidently, serum orosomucoid constitutes an useful index in diagnosis and monitoring of bacterial infections in the neonatal period.


The following articles in journals at HighWire Press have cited this article:


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 JPEN J Parenter Enteral NutrHome page
B. Claxton
The Prognostic Inflammatory and Nutritional Index in Traumatized Patients Receiving Enteral Nutrition Support K. L. VEHE, R. O. BROWN, D. A. KUHL, ET AL Journal of The American College of Nutrition 10:355-363, 1991
JPEN J Parenter Enteral Nutr, January 1, 1992; 16(1): 85 - 86.
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Copyright © 1981 by the American Association for Clinical Chemistry.