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Clinical Chemistry 27: 742-744, 1981;
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Clinical Chemistry, Vol 27, 742-744, Copyright © 1981 by American Association for Clinical Chemistry

Hydrophobic compounds interfere in radioimmunoassay for basic protein in myelin

WB Macklin, MB Lees, SR Cohen and SB Ayella

Hydrophobic compounds influenced the accuracy of the radioimmunoassay for myelin basic protein when lipids (stearic acid, phosphatidylcholine, cholesterol, cerebroside, sulfatide, or GM1 ganglioside) or proteolipids (white-matter proteolipid apoprotein, kidney proteolipid apoproteins, or heart proteolipid apoproteins) were added to a known amount of basic protein and the samples assayed. All of these interfere with the assay, but the direction of the error depends on the quantity added: low concentrations of lipid decrease apparent basic protein, high concentrations enhance it. Obviously, results of basic-protein assays must be interpreted carefully.




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Copyright © 1981 by the American Association for Clinical Chemistry.