Clinical Chemistry
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Clinical Chemistry 27: 846-848, 1981;
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Clinical Chemistry, Vol 27, 846-848, Copyright © 1981 by American Association for Clinical Chemistry

Bile acid assays as an index of cholestasis

DD Woodman and PA Maile

Four bile acid profiles, bilirubin, alkaline phosphatase, alanine aminotransferase, glutamate dehydrogenase, and isocitrate dehydrogenase were measured in rats in which normal bile flow had been disturbed either by administration of alpha-naphthylisothiocyanate or by surgical ligation of the bile duct. The most sensitive index to the early onset of cholestasis was an increase in total cholate. This increase was measurable before morphological changes could clearly be identified.




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Copyright © 1981 by the American Association for Clinical Chemistry.