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Clinical Chemistry 27: 926-929, 1981;
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Clinical Chemistry, Vol 27, 926-929, Copyright © 1981 by American Association for Clinical Chemistry

Automated discrete kinetic method for erythrocyte acetylcholinesterase and plasma cholinesterase

PJ Lewis, RK Lowing and D Gompertz

We describe an automated kinetic method for erythrocyte acetylcholinesterase (EC 3.1.1.7) and plasma cholinesterase (EC 3.1.1.8) based on Ellman's colorimetric method. Quinidine sulfate is used as an inhibitor of plasma cholinesterase during the measurement of erythrocyte acetylcholinesterase activity, obviating the need for washing the erythrocytes before lysis. Results by this method are compared with those obtained by the electrometric delta pH method of Michel. To emphasize the need for measuring both erythrocyte acetylcholinesterase and plasma cholinesterase activity in workers exposed to organophosphate pesticides, we present a study of serial activities of both enzymes in a person accidentally exposed to demeton- S-methyl.


The following articles in journals at HighWire Press have cited this article:


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 Hum Exp ToxicolHome page
H J Mason, C Sams, A J Stevenson, and R Rawbone
Rates of spontaneous reactivation and aging of acetyicholinesterase in human erythrocytes after inhibition by organophosphorus pesticides
Human and Experimental Toxicology, September 1, 2000; 19(9): 511 - 516.
[Abstract] [PDF]

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 Hum Exp ToxicolHome page
C Sams and H J Mason
Detoxification of organophosphates by A-esterases in human serum
Human and Experimental Toxicology, November 1, 1999; 18(11): 653 - 658.
[Abstract] [PDF]


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Copyright © 1981 by the American Association for Clinical Chemistry.