Clinical Chemistry AACC Online Job Center
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 27: 1210-1212, 1981;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hurst, H. E.
Right arrow Articles by deBree, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hurst, H. E.
Right arrow Articles by deBree, H.

Clinical Chemistry, Vol 27, 1210-1212, Copyright © 1981 by American Association for Clinical Chemistry

Determination of clovoxamine concentration in human plasma by electron capture gas chromatography

HE Hurst, DR Jones, CH Jarboe and H deBree

The antidepressant drug clovoxamine can be specifically and sensitively quantitated in human plasma by electron capture gas chromatography. Clovoxamine and the internal standard fluvoxamine are extracted into ethyl acetate from plasma at pH 12, back-extracted into phosphoric acid, and hydrolyzed at 90 degrees C to form ketone derivatives, which are then re-extracted into hexane for injection into the chromatograph. As little as 1 microgram of clovoxamine per liter of plasma can be measured. The coefficients of variation (CV) for th analysis at concentrations of 10 and 100 micrograms/L are respectively: within-run, 5.4% and 2.7%; between-run, 17.5% and 7.0%. When this assay was applied to plasma from individuals involved in an early clinical trial of clovoxamine, steady-state plasma concentrations ranged from 50 to 77 micrograms/L 3 h after a 50-mg oral dose of clovoxamine fumarate.


The following articles in journals at HighWire Press have cited this article:


Home page
 J PsychopharmacolHome page
A. Goldie and J. G. Edwards
Effect of clovoxamine fumarate on the electrocardiogram
J Psychopharmacol, January 1, 1989; 3(1): 29 - 31.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by the American Association for Clinical Chemistry.