Clinical Chemistry
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Clinical Chemistry 27: 1463-1464, 1981;
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Clinical Chemistry, Vol 27, 1463-1464, Copyright © 1981 by American Association for Clinical Chemistry

Hyperlabile diabetes accompanied by insulin resistance

A Renie, RG Hamilton, NF Adkinson Jr and MS Rendell

It is generally held that high insulin antibody concentrations, by "buffering" abrupt swings in free insulin concentrations after injections of exogenous insulin, tend to stabilize blood glucose variations in diabetic patients. However, we encountered a patient with extremely labile diabetes coexisting with insulin resistance. This patient's injections were switched to pure porcine insulin from his usual mixed bovine/porcine insulin, in an effort to decrease his insulin requirement. This treatment was successful, and, as his insulin dosage decreased, his diabetic lability diminished substantially. His diabetes was eventually considered stabilized on about 22 units of porcine insulin daily. The serial decrease in his insulin antibody concentrations, monitored by use of solid-phase radioimmunoassay, paralleled the disappearance of his diabetic lability as well as the decrease in his insulin requirement.


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 Endocr. Rev.Home page
S. E. Fineberg, T. T. Kawabata, D. Finco-Kent, R. J. Fountaine, G. L. Finch, and A. S. Krasner
Immunological Responses to Exogenous Insulin
Endocr. Rev., October 1, 2007; 28(6): 625 - 652.
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Copyright © 1981 by the American Association for Clinical Chemistry.