Clinical Chemistry
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Clinical Chemistry 28: 2100-2102, 1982;
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Clinical Chemistry, Vol 28, 2100-2102, Copyright © 1982 by American Association for Clinical Chemistry

Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection

JF Nash, RJ Bopp, RH Carmichael, KZ Farid and L Lemberger

This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detection is 25 to 800 micrograms/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 micrograms/L for both drugs was approximately 10%. Accuracy (relative error) in the same concentration range was approximately +10%. None of the commonly prescribed antidepressants or tranquilizers that we tested interfere with the assay.




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Copyright © 1982 by the American Association for Clinical Chemistry.