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Clinical Chemistry 28: 2121-2124, 1982;
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Clinical Chemistry, Vol 28, 2121-2124, Copyright © 1982 by American Association for Clinical Chemistry

Turbidimetric immunoassay of serum C-reactive protein

S Otsuji, H Shibata and M Umeda

This rapid, reliable equilibrium turbidimetric immunoassay for serum C- reactive protein involves a potent monospecific antibody. Polyethylene glycol-6000 to accelerate and enhance the immunoprecipitation reaction, and Tween-20 surfactant to lower and stabilize the sample blank values. Grossly lipemic, icteric, or hemolyzed sera can be assayed. Values up to about 220 mg/L, for which the standard curve is linear, can be measured without sample dilution. Results by the proposed method and by radial immunodiffusion (r 0.989) or laser nephelometry (r = 0.957) correlated well. Analytical recovery averaged 101.3%. Within-, between- , and day-to-day CVs ranged from 0.9% to 3.5%, 0.8% to 5.5%, and 1.9% to 4.8%, respectively. The method is demonstrably superior to radial immunodiffusion or nephelometry. Any spectrophotometer that can measure turbidimetrically at 340 nm can be used.


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