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Clinical Chemistry 28: 327-332, 1982;
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Clinical Chemistry, Vol 28, 327-332, Copyright © 1982 by American Association for Clinical Chemistry

Interactions among enzyme, antibody, drug, and time in enzyme immunoassays for drugs of abuse

J Osterloh and GP Butrimovitz

Published information on the major interactive variables of enzymic immunoassays for drugs, whether in urine or serum, is scanty. Using the Syva EMIT-dau Barbiturates assay as an example, we examined the following interactive variables with respect to test response: concentrations of enzyme, antibody, and drug; urine matrix; and time. The results suggest a process for optimizing this type of enzyme immunoassay. Transformation of the data gives indirect evidence of heterogeneous antibody reactions that are drug-concentration dependent.




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Copyright © 1982 by the American Association for Clinical Chemistry.