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Clinical Chemistry 28: 449-452, 1982;
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Clinical Chemistry, Vol 28, 449-452, Copyright © 1982 by American Association for Clinical Chemistry

Sodium ion binding in human serum

TR Kissel, JR Sandifer and N Zumbulyadis

The amount of sodium ion binding in human sera and in dialyzed human sera was estimated from standard-addition titrations with an ion- selective electrode and from measurements of 23Na nuclear magnetic resonance (NMR) linewidth. For the untreated sera, maximum binding was 1% (1.4 mmol/L) as indicated by NMR; virtually no binding was found via the titration method. For dialyzed sera with low-sodium, normal-protein content, NMR indicated that sodium binding was less than 1.3% (0.14 mmol/L). The same dialyzed fluid analyzed with ion-selective electrodes shows no sodium binding, within the limits of experimental error (+/- 4%). Sodium ion binding to serum protein thus contributes only minimally to differences in sodium measurements observed between the direct (undiluted) ion-selective electrode and flame-photometric methods.




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Copyright © 1982 by the American Association for Clinical Chemistry.