Clinical Chemistry
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Clinical Chemistry 28: 1196-1197, 1982;
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Clinical Chemistry, Vol 28, 1196-1197, Copyright © 1982 by American Association for Clinical Chemistry

Theoretical and mathematical conditions for use of linearization methods for saturation-type radioassay data

W Shaw

The algebraic equivalency of nine different methods for the linearization of saturation-type radioassay data was previously demonstrated mathematically to hold under the assumption that the antibody is saturated with ligand. Although compete saturation with antibody never occurs, a good approximation to a saturation condition occurs when the product of the labeled ligand and the affinity constant is 100 or more. The mathematical basis for determining when methods for the linearization of saturation-type radioassay data are valid is derived from a development of the first-order mass action law applied to ligand-antibody reactions.




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Copyright © 1982 by the American Association for Clinical Chemistry.