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Clinical Chemistry 28: 1215-1218, 1982;
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Clinical Chemistry, Vol 28, 1215-1218, Copyright © 1982 by American Association for Clinical Chemistry

Liquid-chromatographic direct determination of phenylalanine and tyrosine in serum or plasma, with application to patients with phenylketonuria

MA Hilton

With this method, picomole amounts of phenylalanine and tyrosine can be rapidly separated and directly measured by absorbance at 206 nm. As little as 25 microliters of serum or plasma suffices. Plasma is deproteinized and 20 microliters of the supernate, representing 1.8 microliters of plasma, is applied to a reversed-phase column and eluted isocratically with a solution containing methanol and H3PO4, pH 2.4. The tyrosine and phenylalanine peaks appear at 6 and 10 min, respectively. We used the method to measure phenylalanine in plasma from six children with phenylketonuria.


The following articles in journals at HighWire Press have cited this article:


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 Journal of the American Animal Hospital AssociationHome page
S. Neumann, H. Welling, and S. Thuere
Evaluation of Serum L-phenylalanine Concentration as Indicator of Liver Disease in Dogs: A Pilot Study
J. Am. Anim. Hosp. Assoc., July 1, 2007; 43(4): 193 - 200.
[Abstract] [Full Text] [PDF]


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Copyright © 1982 by the American Association for Clinical Chemistry.