Clinical Chemistry
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Clinical Chemistry 28: 1346-1348, 1982;
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Clinical Chemistry, Vol 28, 1346-1348, Copyright © 1982 by American Association for Clinical Chemistry

Normalization and reproducibility of mass profiles in the detection of individual differences from urine

R Marcuson, SL Burbeck, RL Emond, GI Latter and W Aberth

The mass profiles of urine samples and their reproducibility (coefficient of variation) obtained by field-ionization mass spectrometry (volcano source) depend upon the choice of normalization method. We compared six different normalization techniques in terms of improved reproducibility and sensitivity. Several simple procedures markedly improved reproducibility while preserving the high degree of sensitivity. Although these procedures gave similar and satisfactory results, others were clearly inferior and are not recommended for clinical profiling.




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Copyright © 1982 by the American Association for Clinical Chemistry.