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Clinical Chemistry 28: 1482-1484, 1982;
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Clinical Chemistry, Vol 28, 1482-1484, Copyright © 1982 by American Association for Clinical Chemistry

Verapamil and calcium-stimulated enzyme efflux from skeletal muscle

R Anand and AE Emery

An early and significant biochemical abnormality in Duchenne's muscular dystrophy is an increase in intracellular calcium. We have found that the "calcium-blocker" drug verapamil inhibits calcium-stimulated efflux of creatine kinase (EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) in vitro from normal human skeletal muscle at therapeutic concentrations. Such a calcium blocker might therefore be useful in the treatment of Duchenne's muscular dystrophy.




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Copyright © 1982 by the American Association for Clinical Chemistry.