Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 28: 1946-1955, 1982;
This Article
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pinkerton, T. C.
Right arrow Articles by Lawson, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pinkerton, T. C.
Right arrow Articles by Lawson, B. L.

Clinical Chemistry, Vol 28, 1946-1955, Copyright © 1982 by American Association for Clinical Chemistry

Analytical problems facing the development of electrochemical transducers for in vivo drug monitoring: an overview

TC Pinkerton and BL Lawson

Even though significant progress has been made in the development of electrodes for the in vivo detection of catecholamines, oxygen, and various cations, there has been little research on the feasibility of continuously monitoring drugs in whole blood by electrochemical sensing devices. Electroanalytical problems associated with the development of such electrochemical transducers include the need for increased sensitivity and specificity, decreased biological matrix interferences, more rapid response times, improved miniaturization, and more reliable calibration procedures. We present a critical evaluation of potentiometric, conductometric, and amperometric techniques, with a brief review of basic principles and recent advances in ion-selective electrodes, chemical-sensing field-effect transistors, amperometric enzyme electrodes, and electrochemical immunosensors.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by the American Association for Clinical Chemistry.