Clinical Chemistry
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Clinical Chemistry 29: 107-109, 1983;
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Clinical Chemistry, Vol 29, 107-109, Copyright © 1983 by American Association for Clinical Chemistry

Multivariate analysis of plasma enzyme profiles in severe head injury

A Bourguignat, G Ferard, G Jung, T Klumpp and P Metais

We followed the changes in the activities of four enzymes (aldolase, aspartate aminotransferase, creatine kinase, and lactate dehydrogenase) in plasma for four days after head injury. The progression of the changes differs significantly between survivors and nonsurvivors. Stepwise discriminant analysis, involving the four enzymes, allowed us to divide 81 to 92% of head-injured patients (n = 280 selected without conscious bias) correctly into the two groups as early as 72 h after trauma. Most of the patients who were misclassified according to our biochemical criteria had received phenobarbital for sedation. Valuable prognostic information in head injury evaluation may thus be obtained by daily determination of enzymatic activities of these four enzymes.


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 Arch Pediatr Adolesc MedHome page
G. W. Brown
Discriminant Analysis
Arch Pediatr Adolesc Med, April 1, 1984; 138(4): 395 - 400.
[Abstract] [PDF]


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Copyright © 1983 by the American Association for Clinical Chemistry.