Clinical Chemistry
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Clinical Chemistry 29: 158-160, 1983;
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Clinical Chemistry, Vol 29, 158-160, Copyright © 1983 by American Association for Clinical Chemistry

Measurement of nifedipine in plasma by gas--liquid chromatography and electron-capture detection

SR Hamann and RG McAllister Jr

In this method for measuring nifedipine, a calcium-channel inhibitor now widely used in the treatment of cardiovascular disease, the drug is extracted from plasma under basic conditions into toluene, and an aliquot of the extract is injected directly into a gas chromatograph equipped with an OV-101 column and an electron-capture detector. The standard curve is linear between 1 and 100 micrograms/L; the assay measures not only nifedipine, but also a major metabolic product (found only after oral administration of the parent drug) and photodegradation products. The procedure is rapid and adequately sensitive for routine use in clinical monitoring of nifedipine in plasma.


The following articles in journals at HighWire Press have cited this article:


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 PerfusionHome page
G. Noera, C. Massini, and G. Baggio
In vitro plasma nifedipine concentration during heart-lung machine function
Perfusion, October 1, 1987; 2(4): 277 - 281.
[Abstract] [PDF]

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 JAMAHome page
M. Traube, M. Hongo, L. Magyar, and R. W. McCallum
Effects of Nifedipine in Achalasia and in Patients With High-Amplitude Peristaltic Esophageal Contractions
JAMA, October 5, 1984; 252(13): 1733 - 1736.
[Abstract] [PDF]


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Copyright © 1983 by the American Association for Clinical Chemistry.