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Clinical Chemistry 29: 45-47, 1983;
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Clinical Chemistry, Vol 29, 45-47, Copyright © 1983 by American Association for Clinical Chemistry

Evolutionary changes in acute-phase proteins in alcoholic hepatocellular diseases

C Perier, A Chamson, R Engler and J Frey

We studied the pattern of acute-phase proteins (orosomucoid, C-reactive protein, and haptoglobin) in hepatocellular deficiency due to chronic alcohol consumption, characterized by a decrease in serum transferrin concentration. We found that their patterns could vary independently of hepatocellular deficiency, but depend on the progression of hepatic disease. The most useful protein for discriminating the stage of inflammatory reaction is orosomucoid. In moderate hepatocellular deficiency, acute-phase proteins are increased independently of the decrease in transferrin, whereas in severe hepatocellular deficiency the acute-phase proteins are also decreased. Thus, it is possible to distinguish the two stages of hepatocellular deficiency by following changes in the concentration of orosomucoid.


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Copyright © 1983 by the American Association for Clinical Chemistry.