Clinical Chemistry
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Clinical Chemistry 29: 1796-1798, 1983;
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Clinical Chemistry, Vol 29, 1796-1798, Copyright © 1983 by American Association for Clinical Chemistry

Direct measurement of testosterone in a pediatric center, with use of a radioimmunoassay kit and unextracted serum

LJ Funderburgh, WB Zipf and JF Sotos

We evaluated a commercial (Radioassay Systems) radioimmunoassay kit for testosterone in which a double-antibody method and an 125I tracer are used. The 50-microL serum sample is assayed directly with no pre- extraction step. The assay system has good sensitivity (0.01 microgram/L), good precision (CV 5.2%), and little cross reactivity between testosterone and other androgens. Results compared well with those by a tritiated radioimmunoassay involving extraction (r = 0.98). Values obtained for 97 children compared well with published pediatric normal values. Evidently, this kit provides a rapid and reliable measurement of testosterone in serum specimens and is acceptable for use with pediatric patients.




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Copyright © 1983 by the American Association for Clinical Chemistry.