Clinical Chemistry
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Clinical Chemistry 29: 1842-1844, 1983;
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Clinical Chemistry, Vol 29, 1842-1844, Copyright © 1983 by American Association for Clinical Chemistry

A unique protein in normal human cerebrospinal fluid

NM Papadopoulos, PA LeWitt, RP Newman, MI Raphaelson and TN Chase

On analysis of cerebrospinal fluid (CSF) samples from normal volunteer donors by high-resolution zone electrophoresis on agarose gel, an electrophoretically homogeneous protein band consistently appeared in the gamma-globulin region. Application of immunofixation electrophoresis in attempts to identify the band with use of monospecific antibodies against individual human serum proteins and against heavy- and light-chain immunoglobulins as well as polyvalent antisera did not produce a positive immunoprecipitation reaction with the protein band. The serum samples from these subjects did not show similar bands. Therefore, we conclude that this protein band is a normally occurring protein that is unique to CSF.




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Copyright © 1983 by the American Association for Clinical Chemistry.