Clinical Chemistry
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Clinical Chemistry 29: 1850-1851, 1983;
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Clinical Chemistry, Vol 29, 1850-1851, Copyright © 1983 by American Association for Clinical Chemistry

Hepatic infarction: biochemical study of a case

GN Hoag, TP Orr and DR Amies

Hepatic infarction was observed post mortem in a 27-year-old man who died of aortic dissection. Blood had been sampled at admission and 12 and 19 hours later. Values for aspartate aminotransferase and alanine aminotransferase in serum were markedly above normal, whereas those for alkaline phosphatase and gamma-glutamyltransferase were only marginally increased. A threefold-increased creatine kinase was ascribable solely to isoenzyme CK-3, suggesting muscle breakdown. Moreover, total lactate dehydrogenase activity was increased threefold, accounted for by a ninefold increase in LD-5 isoenzyme. Those enzyme activities in serum that evidently are associated with acute hepatocellular necrosis increase quickly in hepatic infarction, and CK isoenzyme assay is a useful adjunct if LD-5 increases are significant.





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Copyright © 1983 by the American Association for Clinical Chemistry.