Clinical Chemistry
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Clinical Chemistry 29: 2086-2088, 1983;
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Clinical Chemistry, Vol 29, 2086-2088, Copyright © 1983 by American Association for Clinical Chemistry

Discrepancies in measurement of aspartate aminotransferase by continuous-flow analysis

P West

I compared results for aspartate aminotransferase (EC 2.6.1.1) obtained with a reaction-rate analyzer (LKB 2086 Mark Two), based on IFCC methodology, and a continuous-flow analyzer (the Technicon SMA 2) for 115 patients' sera and seven commercial quality-control sera. The data from the SMA 2 showed a clear positive bias in those sera with activities exceeding 40 U/L (the upper limit of the reference range). Independent data to support the bias of the SMA 2 and other continuous- flow analyzer systems are presented. Application of a correction factor to the SMA 2 data above the upper limit of the range significantly decreased this bias. Failure to apply such a factor to data obtained from continuous-flow analyzers could lead to serious clinical misinterpretation.




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Copyright © 1983 by the American Association for Clinical Chemistry.