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Clinical Chemistry 29: 358-361, 1983;
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Clinical Chemistry, Vol 29, 358-361, Copyright © 1983 by American Association for Clinical Chemistry

Evaluation of an enzymic procedure for the measurement of acetaminophen

CP Price, PM Hammond and MD Scawen

We evaluated a new method for measurement of acetaminophen. From acetaminophen, acetate and p-aminophenol are enzymically produced, and the latter product is determined colorimetrically by reaction with o- cresol and ammoniacal copper sulfate. The method is rapid and precise, and results compare well with those by spectrophotometric and liquid- chromatographic techniques. Major metabolites of acetaminophen, some commonly used drugs, or phenolic substances that may be present in patients with liver or renal disease do not interfere.


The following articles in journals at HighWire Press have cited this article:


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C. Severijnen, E. Abrahamse, E. M. van der Beek, A. Buco, B. J. M. van de Heijning, K. van Laere, and H. Bouritius
Sterilization in a Liquid of a Specific Starch Makes It Slowly Digestible In Vitro and Low Glycemic in Rats
J. Nutr., October 1, 2007; 137(10): 2202 - 2207.
[Abstract] [Full Text] [PDF]


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Copyright © 1983 by the American Association for Clinical Chemistry.