Clinical Chemistry
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Clinical Chemistry 29: 382-384, 1983;
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Clinical Chemistry, Vol 29, 382-384, Copyright © 1983 by American Association for Clinical Chemistry

Immunoglobulin-complexed aspartate aminotransferase

N Weidner, JA Lott, VD Yale, RL Wahl and RA Little

We report two cases of unexplained, isolated, persistently increased aspartate aminotransferase activity in serum. In the first patient, this lasted for 10 years and prompted multiple hospitalizations and medical/surgical consultations. For patient two, the abnormal enzyme activity resulted in hospitalization for further evaluation of possible heart disease. In spite of extensive investigation to determine the possible reason for the abnormality, no clear clinical cause was ever discovered in either patient. Electrophoretic and immunologic evidence indicates that the enzyme was complexed to IgG in the serum of both individuals. Recognition that this complex is probably benign may obviate other patients having to undergo unnecessary hospitalization, anxiety, and expense.


The following articles in journals at HighWire Press have cited this article:


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Ann Clin BiochemHome page
R. Lord, M. Fahie-Wilson, and S. Suri
A paediatric case of macro aspartate aminotransferase
Ann Clin Biochem, May 1, 2008; 45(3): 323 - 324.
[Abstract] [Full Text] [PDF]


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Clin. Chem.Home page
K. Asanuma, A. Yagihashi, and N. Watanabe
Characterization of the Aspartate Aminotransferase–Immunoglobulin M Complex in a Japanese Woman,
Clin. Chem., April 1, 1997; 43(4): 686 - 687.
[Full Text] [PDF]




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Copyright © 1983 by the American Association for Clinical Chemistry.