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Clinical Chemistry, Vol 29, 549-552, Copyright © 1983 by American Association for Clinical Chemistry
BC Del Villano, S Brennan, P Brock, C Bucher, V Liu, M McClure, B Rake, S Space, B Westrick, H Schoemaker and VR Zurawski Jr
We describe a solid-phase radioimmunometric sandwich assay for a new tumor marker defined by a monoclonal antibody (19-9). This antibody reacts with a carbohydrate antigenic determinant (CA 19-9) found at low concentrations in sera from healthy individuals but frequently increased in sera from patients with adenocarcinomas. The assay is sensitive and simple to perform. It requires duplicate 100-microL samples and may be performed in 6 h. The concentration of CA 19-9 in samples is determined by reference to a standard curve, which is essentially linear from 0 to 120 arbitrary units/mL. The average CV is approximately 10% in the range of 5.8 to 120 units/mL. The minimum detectable dose is 1.4 units/mL and analytical recovery of CA 19-9 is 97.6 to 100.6%. The average concentration of CA 19-9 in sera from 1020 healthy individuals was 8.4 (SD 7.4) units/mL; only 0.6% of such sera had concentrations greater than 37 units/mL. The assay has high specificity (98.5%), even among patients with benign diseases, and has high sensitivity (up to 79%) for patients with gastrointestinal adenocarcinomas, especially those of the pancreas.
The following articles in journals at HighWire Press have cited this article:
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J. Hedstrom, C. Haglund, E. Kemppainen, M. Leinimaa, J. Leinonen, and U.-H. Stenman Time-resolved Immunofluorometric Assay of Trypsin-1 Complexed with {alpha}1-Antitrypsin in Serum: Increased Immunoreactivity in Patients with Biliary Tract Cancer Clin. Chem., October 1, 1999; 45(10): 1768 - 1773. [Abstract] [Full Text] [PDF]
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R. Brandl, R. Probst, B. Muller, S. Powarzynski, P. C. Maurer, and D. Neumeier Evaluation of the Measurement of Lysate Homocysteine in Patients with Symptomatic Arterial Disease and in Healthy Volunteers Clin. Chem., May 1, 1999; 45(5): 699 - 702. [Full Text] [PDF]
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C. P. Price The Evolution of Immunoassay as Seen Through the Journal Clinical Chemistry Clin. Chem., October 1, 1998; 44(10): 2071 - 2074. [Full Text] [PDF]
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R. Probst, R. Brandl, M. Blumke, and D. Neumeier Stabilization of Homocysteine Concentration in Whole Blood Clin. Chem., July 1, 1998; 44(7): 1567 - 1569. [Full Text] [PDF]
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 J. Blacher, K. Demuth, A. P. Guerin, M. E. Safar, N. Moatti, and G. M. London Influence of Biochemical Alterations on Arterial Stiffness in Patients With End-stage Renal Disease Arterioscler Thromb Vasc Biol, April 1, 1998; 18(4): 535 - 541. [Abstract] [Full Text] [PDF]
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 D. K. Pleskow, H. J. Berger, J. Gyves, E. Allen, A. McLean, and D. K. Podolsky Evaluation of a Serologic Marker, CA19-9, in the Diagnosis of Pancreatic Cancer Ann Intern Med, May 1, 1989; 110(9): 704 - 709. [Abstract] [PDF]
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