| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Clinical Chemistry, Vol 29, 684-687, Copyright © 1983 by American Association for Clinical Chemistry
J Toffaletti, N Blosser, T Hall, S Smith and D Tompkins
We evaluated an automated dry-slide enzymatic method involving creatinine iminohydrolase for measurement of creatinine in serum with the Kodak Ektachem analyzer. The means (and SD) for three commercially available quality-control sera, analyzed during eight weeks, were 9.7 (1.0), 16.6 (0.9), and 61 (2.1) mg/L. The regression equation for 105 samples measured with the Technicon SMAC (x) and Ektachem Analyzers (y) was: y = (0.89 +/- 0.007)x + (1.7 +/- 0.3) mg/L and for 170 samples measured with the Beckman Astra (x) and Ektachem analyzers (y): y = (1.00 +/- 0.005)x - (1.9 +/- 0.16) mg/L. Sixty-one samples from renal- transplant patients showed nearly the same agreement. The enzymatic method had no interference from substances that interfere with many Jaffe methods for creatinine, including acetoacetate. The drugs cephalothin and cephoxitin did not interfere, but 5-fluorocytosine interfered significantly with creatinine in the Ektachem method. Values for several ketone-positive sera were 5 to 10 mg/L higher by the Astra relative to the Ektachem. Grossly hemolyzed or lipemic samples were analyzed without difficulty. We conclude that this enzymatic method for creatinine in serum has the speed and precision necessary for routine clinical laboratory use and, except for one drug, the method appears to be specific for creatinine.
The following articles in journals at HighWire Press have cited this article:
|
|
 |
|
  R. Botev, J.-P. Mallie, C. Couchoud, O. Schuck, J.-P. Fauvel, J. F.M. Wetzels, N. Lee, N. G. De Santo, and M. Cirillo Estimating Glomerular Filtration Rate: Cockcroft-Gault and Modification of Diet in Renal Disease Formulas Compared to Renal Inulin Clearance Clin. J. Am. Soc. Nephrol., May 1, 2009; 4(5): 899 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. P Barbagallo, N. Boley, G. Holcombe, S. Merson, C. Mussell, C. Pritchard, P. Stokes, S. Wood, D. Ducroq, and A. Thomas Production and certification of four frozen human serum certified reference materials containing creatinine and electrolytes Ann Clin Biochem, March 1, 2008; 45(2): 160 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Van Biesen, R. Vanholder, N. Veys, F. Verbeke, J. Delanghe, D. De Bacquer, and N. Lameire The importance of standardization of creatinine in the implementation of guidelines and recommendations for CKD: implications for CKD management programmes Nephrol. Dial. Transplant., January 1, 2006; 21(1): 77 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Myers, W. G. Miller, J. Coresh, J. Fleming, N. Greenberg, T. Greene, T. Hostetter, A. S. Levey, M. Panteghini, M. Welch, et al. Recommendations for Improving Serum Creatinine Measurement: A Report from the Laboratory Working Group of the National Kidney Disease Education Program Clin. Chem., January 1, 2006; 52(1): 5 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sharma, P. McCue, and S. R. Dunn Diabetic kidney disease in the db/db mouse Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1138 - F1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Meneton, I. Ichikawa, T. Inagami, and J. Schnermann Renal physiology of the mouse Am J Physiol Renal Physiol, March 1, 2000; 278(3): F339 - F351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Herrington, G. L. Drusano, U. Smalls, and H. C. Standiford False Elevation in Serum Creatinine Levels JAMA, December 7, 1984; 252(21): 2962 - 2962. [Abstract] [PDF]
|
|
|
|
 |
|
 E. K. MITCHELL Flucytosine and False Elevation of Serum Creatinine Level Ann Intern Med, August 1, 1984; 101(2): 278 - 278. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
