Clinical Chemistry
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Clinical Chemistry 29: 869-870, 1983;
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Clinical Chemistry, Vol 29, 869-870, Copyright © 1983 by American Association for Clinical Chemistry

Characteristics of high-affinity folate binding in human leukocytes

J Holm, SI Hansen and J Lyngbye

High-affinity binding of [3H]folate in leukocytes from normal subjects was studied in equilibrium dialysis experiments (pH 7.4, 37 degrees C). Binding displayed positive cooperativity, and the binding affinity increased with decreasing concentration of the binding protein. Both phenomena could be interpreted in terms of ligand binding to a polymerizing system where the affinity of ligand for the oligomer is greater than its affinity for the polymer prevailing at higher concentrations of the binding protein.




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Copyright © 1983 by the American Association for Clinical Chemistry.