Clinical Chemistry
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Clinical Chemistry 29: 1363-1366, 1983;
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Clinical Chemistry, Vol 29, 1363-1366, Copyright © 1983 by American Association for Clinical Chemistry

Metabolism of creatinine in vivo

M Boroujerdi and AM Mattocks

Two forms of radiolabeled creatinine were used in this study, [carbonyl- 14C]- and [amidino-14C]creatinine, the latter being synthesized in this laboratory. These labeled compounds were given intravenously to rabbits. Specimens of plasma, urine, feces, and selected tissues were collected. These were liquid-chromatographed and the separated components compared for radioactivity and identity. This first use of amidino-labeled creatinine revealed the metabolic conversion of small amounts of creatinine to an unidentified non-basic compound and guanidinobutyrate in normal rabbits and to guanidinopropionic acid and arginine in a rabbit that had a low creatinine clearance. A mechanism is suggested for this metabolic process. The proposed pathway may be a major route of elimination of creatinine in renal failure.


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M. Wyss and R. Kaddurah-Daouk
Creatine and Creatinine Metabolism
Physiol Rev, July 1, 2000; 80(3): 1107 - 1213.
[Abstract] [Full Text] [PDF]

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 JPEN J Parenter Enteral NutrHome page
M. Walser
Creatinine Excretion as a Measure of Protein Nutrition in Adults of Varying Age
JPEN J Parenter Enteral Nutr, September 1, 1987; 11(5_suppl): 73S - 78S.
[Abstract] [PDF]


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Copyright © 1983 by the American Association for Clinical Chemistry.